Journal Publications

Journal Publications

One good place to begin is with PubMed. It is comprised of more than 19 million citations for biomedical articles from MEDLINE and life science journals. Citations may include links to full-text articles from PubMed Central or publisher web sites.

Any investigation will benefit from an approach that considers multiple aspects of the same problem. Bone biology and osteoporosis is no different. Below are three citations to published papers that demonstrate that diversity of thought is illuminating to the subject under consideration.

How does human bone resist fracture?
Richie R.O. (Department of Materials Science and Engineering, University of California, Berkeley, CA, USA.)Ann N.Y. Acad. Sci. (2010) 1192: 72-80.
Someone with an engineering background will view the problem of fracture in bone loss in a different light to a clinically trained individual. In his paper Professor Richie asks the question about the change in quality of bone with time – as opposed to the more widely explored issue of how much bone is lost from the stock over time. This paper seeks to describe that bone derives its resistance to fracture from “a multitude of deformation and toughening mechanisms at many of these size-scales, ranging from the nanoscale structure of its protein molecules to its macroscopic physiological state”

A meta-analysis of brief high-impact exercises for enhancing bone health in premenopausal women.
Babatunde OO, Forsyth JJ, Gidlow CJ. (Centre for Sport, Health and Exercise Research, Staffordshire University, Leek Road, Stoke on Trent, ST4 2DF, UK) Osteoporos Int. 2011 Sep 28.

Many people now understand the value of exercise, or as it is sometimes referred to in learned circles ‘mechanical loading’, on maintaining a healthy skeleton. Long spells of bed rest cause loss of muscle and bone. However, exercise takes many forms and making assessments of effects is often complicated by the problems associated with the nature of the exercise that different protocols adopt. The sports scientists from Staffordshire University have attempted to investigate this area by looking at several exercise studies to ask the question does brief high-impact exercise produce significant benefit to the bone in the spine and at the hip (top of the long bone in the leg; the femur). These researchers found 6 randomised controlled studies that could be pulled together for consideration and investigated as a whole (meta-analysis). The overall conclusions were that brief high-impact exercise can be quantified to show increases in the amount of bone at the hip, but the spine showed little benefit. Concluding that “effectiveness of this form of exercise as a lifestyle physical activity for prevention of osteoporosis should be explored in larger populations”.